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The proposed acquisition of Metsera aligns with our focus on directing our investments to the most impactful opportunities and propels Pfizer into this key therapeutic area, said Albert Bourla, Chairman and Chief Executive Officer, Pfizer in a company press release

This inhibition consecutively leads to post-prandial GLP-1 plasma concentrations that are elevated 2-3-fold and mediates the glucose-dependent stimulation of insulin secretion and inhibition of glucagon secretion (Table 1 gives a summary of the clinical phase III studies with at least 52 weeks duration on the efficacy of DPP-4 inhibitors compared to sulfonylureas as add on therapy to metformin, respectively, in patients not reaching their glycaemic goals with a monotherapy of metformin

This estimate does not include rebates, which Medicares actuaries estimated to be 31.5% overall in 2022 but could be as high as 69% for Ozempic, according to one estimate

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Arthritis burden report