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In addition, a multicenter, randomized controlled trial in patients with T2DM without cardiovascular disease also found that the mean carotid intimal thickness and left carotid intimal thickness after sitagliptin treatment were significantly reduced from baseline, with no significant difference on the right side

The molecular weights are similar, and the difference only comes from the methyl substitution of glycine (Gly) and alanine (Ala)

Jia, S., He, D

Dosing regimens typically start at 500 mg twice daily, titrated up to 1.53 grams per day [5]

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