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Statistical Analysis In line with EMA, FDA and PMDA guidelines, a crossover design was chosen to leverage the lower within-participant variability in PK measures and thereby limit the number of participants required for the study [28,29,30]

in colonocytes, oxygen consumption with oxidation of butyrate by colonocytes gives CO 2 and ATP, and this is associated with water and sodium absorption 25

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These types of inhibitors may exhibit better inhibitory effects