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Assays, biomarkers, and phenotypic endpoints Biochemical and transcriptional readouts ERR target-gene panels spanning fatty-acid uptake/-oxidation (Cpt1b, Acadl/Acadm), OXPHOS (Ndufs, Uqcrc, Cox), TCA (Cs, Idh), and mitochondrial biogenesis (Ppargc1a, Tfam) provide proximal pharmacodynamic evidence of receptor engagement

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HPLC analysis of ASHMI and its individual herbs and extracts have been reported for standardization according to guidelines issued by the US Food and Drug Administration Guidance for Industry Botanical Drug Products, 7.1 Asthma Li et al

Cholinergic dysfunction, mediated by decreased choline acetyltransferase activity, disrupts attention and short-term memory (75)