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However, more large-scale randomized controlled trials (RCTs) are required to verify the neuroprotective effects of metformin

As the population of older adults grows and the wider clinical acceptance of therapies increases, the adoption rate is speeding up

Inhibition of Glucagon Release GLP-1 helps regulate blood sugar by inhibiting glucagon, a hormone that triggers the liver to release stored glucose, which can raise blood sugar levels

MD simulations were performed using the GROMACS 2018 package 41 with isothermalisobaric (NPT) ensemble and periodic boundary condition

if you become pregnant whilst on treatment, stop the medication and seek immediate medical and nutritional review [1] [25] Contact your GP urgently if you experience: Severe, persistent abdominal pain (with or without vomiting) which could indicate pancreatitis Upper-right abdominal pain, fever or jaundice which may suggest gallbladder disease Persistent nausea or vomiting preventing adequate nutrition Signs of dehydration (dark urine, dizziness, reduced urination) Unexplained symptoms such as jaundice, severe fatigue, or mood changes For people with diabetes: hypoglycaemia (low blood sugar) symptoms when taking insulin or sulfonylureas alongside GLP-1 therapy Regular monitoring throughout GLP-1 treatment should include periodic assessment of weight, body composition where possible, nutritional intake, and relevant blood markers