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Unlike small-molecule drugs that are chemically stable across a wide range of conditions, peptides can hydrolyze, oxidize, and aggregate under conditions most people would consider normal, such as room temperature, moderate humidity, or standard kitchen lighting

This review critically evaluated the historical evidence for iron-dependent LPO as a mechanism of drug-induced hepatotoxicity and explored how these earlier findings have led to the current concept of ferroptosis

The tendencies in the timing of biomarker measurement were similar regardless of treatment, although metformin initiators had a higher probability of having their biomarker levels measured in general (Figure S8)

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