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Other syndromic traits were observed in both patients, including seizures, developmental delay, cognitive impairment, microcephalism, hypogonadism, dental abnormalities, and reticular skin pigmentation

However, other studies have indicated that nutritional stress resulting from Gln deprivation may promote tumor development

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[148] Dependence and withdrawal Drug tolerance develops rapidly in amphetamine abuse (i.e., recreational amphetamine use), so periods of extended abuse require increasingly larger doses of the drug in order to achieve the same effect

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