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doi: 10.1080/07315724.2019.1599745 149 MatsuzawaYNakahashiHKonishiMSatoRKawashimaCKikuchiSet al

Unprocessed blots for Fig

Adding exogenous IGF-1 LR3 creates a powerful dual-pathway anabolic effect

One intriguing hypothesis is that AgRP neurons, which are activated by prolonged fasting and necessary for adequate feeding response to negative energy balance in rodents, and which are inhibited by GLP-1RAs (68, 76, 93, 158, 159), could represent a key neural target for weight loss maintenance (160)

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