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La marca de nacimiento prevalece entre los pueblos del este, sur, sudeste, norte y centro de Asia, los indgenas de Oceana (principalmente micronesios y polinesios), ciertas poblaciones en frica, [1] nativos americanos, [2] latinoamericanos no europeos, caribeos de origen mestizo y turcos

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Conversely, constipation may lead to hard stools, straining, and hemorrhoidal engorgement

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The GLP-1 component activates hepatic AMPK/SIRT1 pathways, which inhibit SREBP-1c, a master regulator of de novo lipogenesis, thereby reducing hepatic triglyceride synthesis (37, 38)