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GSH is manufactured in the cytosol by a two-step process: the first step, which combines cysteine and glutamate, is catalyzed by -glutamylcysteine synthetase (GCS)

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Therefore, for the reasons previously discussed, we believe that payer-specific negotiated charges provide greater insight into the resource use of a hospital

Response: We note that many of the factors recommended are provider-level characteristics, and as such are not feasible to use as a patient characteristic for stratification

FDA will ultimately determine whether to approve or reject the committees recommendations