[Google Scholar] 36.Grgic T, Grgic D, Drmic D, Sever AZ, Petrovic I, Sucic M, Kokot A, Klicek R, Sever M, Seiwerth S, et al
Yaikwawong and colleagues (Yaikwawong et al., 2025) reported in a 12-month randomized controlled trial in 78 patients with T2D and MASLD that 1,500 mg/day curcumin significantly reduced TNF-, IL-1, IL-6, and malondialdehyde levels at all follow-up intervals (3, 6, 9, and 12 months) while increasing antioxidant enzyme activities (glutathione peroxidase, superoxide dismutase) and significantly improving hepatic steatosis and liver stiffness measured by FibroScan
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Individuals with genetic variants associated with reduced GST activity or impaired antioxidant enzyme function may require higher glutathione support or more frequent dosing schedules
And while not mentioned by other reviewers, I definitely have noticed an improvement in my skin tone and hair