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These include: Acute gallbladder disease (added to warning label in March 2022) Acute problems Acute pancreatitis Diabetic retinopathy complications in patients with type 2 Diabetes Gastrointestinal obstruction Ileus (added to the warning label in September 2023) Heart rate increase Hypoglycemia Possible thyroid tumors, including cancer Severe allergic reactions and hypersensitivity reactions, including anaphylaxis and angioedema Suicidal thoughts or behavior If you are taking Wegovy or any other GLP-1 drug like Mounjaro or Rybelsus , contact your doctor if you experience new or worsening side effects

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Metformin commonly causes mild digestive upset, while semaglutide injection may cause nausea, especially in the first few weeks

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Several other genes present on chromosome 21, including SOD1 and APP are directly or indirectly involved in mitochondrial function, contributing to oxidative stress (Izzo et al., 2018) and may thus on their own or in combination with others have an impact on CBS expression and/or activity