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Transduction of spermidine and spermine co-transmitters Polyamines interact with a range of receptors and ion channels on the intracellular side of the cell membrane, conveying inward rectification in some cases and acting as modulators in others (Moriyama et al., 2020)

Adverse events There was no statistically significant difference in the incidence of adverse events between treatment groups (Table 2)

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Data synthesis and analysis In this meta-analysis, weighted mean differences (WMDs) and 95% confidence intervals (CIs) were calculated for continuous measures