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[DOI] [PubMed] [Google Scholar] 111.Balercia G., Buldreghini E., Vignini A., Tiano L., Paggi F., Amoroso S., Ricciardo-Lamonica G., Boscaro M., Lenzi A., Littarru G

in some embodiments, the gel formulation also has an immediate or rapid release component for delivery of the active agent to the desired target site

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It's rare for people to discontinue therapy due to side effects at the 0.25mg starting dose when proper dietary support is in place