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A very large fraction of published binding constants for melanocortin ligands, including those for cyclic analogues, peptidomimetics and candidate subtype-selective compounds, are reported as inhibition of I-NDP-alpha-MSH binding to membranes from cell lines stably expressing a single human receptor subtype

In contrast, OXPHOS inhibition via rotenone or oligomycin elicited heterogeneous responses that were independent of the transcriptional subtype (Supplementary Fig

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