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Physiologically based pharmacokinetic (PBPK) models have been developed for exenatide (1 of 30), dulaglutide (1 of 30), semaglutide (1 of 30), and tirzepatide (2 of 30)

As the incretin effect of GLP-1 is greatly responsible for the insulin secretion after an oral glucose load, we determined the GLP-1 levels after the oral glucose challenge

Expert Opin Pharmacother 2014