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PAGln induced hypercontractility and altered calcium cycling in isolated cardiomyocytes providing evidence of improper relaxation which corresponds to elevated filling pressures observed in vivo

The GSH- and cysteine-conjugates produced are susceptible to thiol exchange reactions and may act as carbamoylating agents towards biomacromolecules (Day et al., 1996

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These findings challenge existing paradigms and provide novel insights into redox homeostasis across subcellular compartments

(2) The removal of the tripeptide sequence (Gly-Pro-Glu) from the N-terminus eliminates a key binding domain for IGFBPs, allowing the peptide to interact more freely with IGF-1 receptors