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Cardiovascular Outcomes Data The SELECT trial (N=17,604) published in the New England Journal of Medicine in 2023 showed that semaglutide 2.4 mg reduced major adverse cardiovascular events by 20% versus placebo in adults with overweight or obesity and established cardiovascular disease, over a mean follow-up of 34 months [11]

Avoid mega-doses of single nutrients without a known deficiency

Instead, variant patterns in these pathways can illuminate metabolic predispositionssuch as genetic appetite-regulation architecture or lipid-metabolizing capacitythat may inform whether a structured metabolic coaching model (like Calibrate's) or a more autonomous telehealth approach (like Ro's) aligns better with a patient's biological and behavioral needs

In addition, 86.4% of those on the treatment lost at least 5% of their body weight, compared with only 31.5% of those on the placebo

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