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In general mB12/LDFA has a significant influence on redox regulation with medium effect sizes, particularly in the role of positively affecting glutathione metabolism and its precursors, whereas BH4 primarily has a positive effect on markers of oxidative damage as well as methylation metabolism with large effect sizes

10.1007/s12035-016-0272-x 298 VintsW

Clemmensen C, Finan B, Mller TD, DiMarchi RD, Tschp MH, Hofmann SM (2019) Emerging hormonal-based combination pharmacotherapies for the treatment of metabolic diseases

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