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Nevertheless, many of them also present insulin resistance and inflammatory cytokine secretion, so it is difficult to determine the exact role of each component in the cardiovascular outcome

Labow BI, Souba WW

Common Endpoints by Route Endpoint Skin firmness or smoothness Topical timeline 8-12 weeks Injectable framing Anecdotal

SURMOUNT-1: Tirzepatide 15 mg The SURMOUNT-1 trial, published in the New England Journal of Medicine in 2022 (N=2,539), showed a mean weight loss of 20.9% with tirzepatide 15 mg at 72 weeks vs