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AOD-9604 Research Protocols & Administration Dosing in Published Research Research investigations have employed diverse AOD-9604 doses across species and administration routes: Rodent studies: 250-500 mcg/kg orally or intraperitoneally was most common for obesity research Rabbit models: 0.25 mg per joint for osteoarthritis studies (intra-articular injection) Pig pharmacokinetic studies: 1.5 mg/kg IV and 2 mg/kg oral for metabolism characterization Human clinical trials: Oral doses of 0.25-10 mg daily

roughly 50-98 % of an administered dose is renally excreted unmetabolized, underscoring the low intrinsic toxicity

Most adults tolerate them well

This is a critical advantage for individuals who want to manage body composition without the challenge of increased hunger that can occur with growth hormone-based approaches

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