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Molecular Profile Molecular Weight 1,419.53 Da Sequence GEPPPGKPADDAGLV (15 amino acids) Purity Spec 98% by HPLC Storage Store lyophilized at 20C

Growth Hormone Antagonist for Proliferative Diabetic Retinopathy Study Group

The brain is constituted by a preponderance of microglia and astrocytes, these glial cells are essential in the Central Nervous System (CNS), with microglia functioning as innate immune cells involved in surveillance and defense, while astrocytes modulate neuronal communication, maintain the extracellular environment, and regulate inflammatory signaling (Garland et al., 2022) Both brain cells are able to produce pro- and anti-inflammatory cytokines (Schwarz and Bilbo, 2012)

Dynamic BBB models were designed to overcome the disadvantages of the transwell models associated with the lack of shear stress and close contact of endothelial cells with neuroglia

This research was supported by the Medical Research Council of Canada and the National Institutes of Health in the United States