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It promotes the growth, differentiation, and survival of neurons by interacting with the HGF/c-Met system, thereby exerting neuroprotective and reparative effects

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Whether these effects add together, overlap, or interfere when the compounds are combined has not been characterized

For instance, glomerular filtration rate, as an index of kidney damage, must be reduced to about 50% before plasma urea and creatinine concentration rise above the upper limit of their respective reference range (Baum et al., 1975)

Melatonin not only regulates the sleep-wake cycle but also serves as a powerful antioxidant that helps reduce oxidative stress and inflammationtwo major contributors to aging and chronic disease Reiter et al., Endocrine , 2006