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Tirzepatide side effects including muscle pain can occur during the first few months and may relate to rapid body composition changes or electrolyte shifts

The problem is that this system can become dysregulated

injections of 10 nmol kg 1 semaglutide ( n = 8 mice), 100 nmol kg 1 GLP-1MK-801 ( n = 8 mice) or vehicle (isotonic saline, n = 8 mice) at a volume of 5 l g 1

That component is what produces the additional 5 to 10 percentage points of weight loss that separates retatrutide from dual agonists

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