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Given the extremely low capacity of hippocampal cells to biosynthesize DHA (reviewed in Plourde and Cunnane, Retained intronic sequences in Gpx4 mRNA In initial experimental strategy used for the detection of the different Gpx4 mRNAs, we designed a couple of primers targeted to exons E1b (forward primer) and the boundary between exons E2/E3 (reverse primer) for the specific detection of nuclear Gpx4 mRNA

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Domperidone should be used at the lowest effective dose for the shortest duration possible and avoided in patients with cardiac conditions, QT prolongation, or those taking other QT-prolonging medications