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In addition, erectile function was improved by 45% in diabetes subjects and by 22% in non-diabetic patients after three months of Pycnogenol intake, assessed with the validated questionnaire International Index of Erectile Function-5 (IIEF-5)

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In these studies, the augmented body weight might correlate with an increase in adipose tissue mass relative to overall body mass

Certain groups should exercise particular caution or avoid BPC-157 entirely: individuals with active cancer or significant cancer history, pregnant or breastfeeding women (no safety data exists), those taking blood thinners (potential interaction effects), and anyone with autoimmune conditions affecting connective tissue