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Decreased 11-HSD2 and increased 11-HSD1 expression were found in placental and amniotic tissue of human pregnancies with intrauterine infection (299, 300)

Steroids should be used with caution in nonspecific ulcerative colitis, if there is a probability of impending perforation, abscess or other pyogenic infection as well as in diverticulitis, fresh intestinal anastomoses, active or latent peptic ulcer

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Its high selectivity and confirmed membrane permeability make it one of the most reliable small-molecule tools currently available for interrogating the NNMT pathway in both cell-based and in vivo experimental models

Glutathione deficiency results in higher susceptibility to oxidative stress, which may lead to poor immune function and faster aging