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LF down-regulated the expression of transforming growth factor--activated kinase 1 and IL-18, restored the level of AKT (Ser 473) phosphorylation in 3T3-L1 cells, and reduced the expression levels of IL-8, IL-6 and MCP-1 genes in subcutaneous and visceral adipocytes ( LF exerts insulin-sensitizing and anti-inflammatory effects by inhibiting the TLR-4/NF-kB/SIRT-1 signaling cascade and correspondingly decreases the expression of serum pro-inflammatory cytokines IL-1, IL-6, lipocalin 2, and TNF-, thereby reducing diabetes-related inflammation (28)

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