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Large population studies have shown that unexplained B12 levels above 813 pg/mL are associated with an increased risk of cancer diagnosis within one year, though the absolute risk for any individual is still relatively low

Therefore, in order to overcome the survival crisis caused by oxidative stress, cancer cells are likely to exhibit metabolic preferences and undergo metabolic reprogramming, including but not limited to GSH metabolic rewiring

The activation of specific signaling pathways, such as the Wnt/-catenin, PI3K/AKT, the adenosine 5-monophosphate (AMP)-activated protein kinase (AMPK), and the MAPK-ERK/1/2 pathways, has been implicated in mediating these therapeutic effects [213, 216]

Theanine may also increase alpha brain waves, which are associated with a state of wakeful relaxation, selective attention mechanisms, arousal and mental alertness