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A study by Yildirim et al

H.p cooperates with S.m to promote caries, enhances the virulence and inflammatory response of P.g in periodontitis, and survives within C.a , which provides it with shelter, helping it resists environmental stresses and antibiotics, thereby aiding its persistence and reinfection (Fan et al., 2025)

Challenges in Research While extensive research supports the benefits of both antioxidants individually as well as their combined effectthere remains ongoing debate about optimal dosing regimens particularly concerning supplementation, which highlights challenges faced by researchers due largely due variability of human physiological responses alongside limitations inherent experimental designs, thus necessitating continued rigorous study under controlled conditions before making definitive conclusions

Patients with thyroid disorders should be closely monitored, and their thyroid hormone levels should be assessed regularly

10.3390/molecules24061123 86 YabeshJ