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GLP-1 and GIP therapy should be considered in people with indicators of high risk or established atherosclerotic cardiovascular disease (ASCVD)

Signs of an allergic reaction include: Do not take Januvia if you are pregnant or think you might be pregnant

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An important aspect of lipid peroxidation is its self-propagating nature and fundamentally different from other forms of free radical injury in that it is a self-sustaining process capable to provoke extensive brain tissue damage (Catal, Nerve cells are endowed with different antioxidant systems that render them protected from oxidative damage caused by lipid peroxides

Whilst retatrutide's glucose-dependent mechanism reduces the theoretical risk of hypoglycaemia when used alone, the risk can increase particularly when it is combined with insulin or sulphonylureas and dose reduction of those medicines may be needed