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CKD affects the bioavailability and pharmacokinetics of direct oral anticoagulants since they are all, at least partially, excreted by the kidneys (the renal clearance of dabigatran is around 80%, of edoxaban 50%, of rivaroxaban 33%, and of apixaban 27%) and may require dose adjustments in patients with reduced eGFR

A clinical study has confirmed elevated expression of NLRP3 inflammasome components in serum samples from pancreatitis patients compared to healthy controls, with NLRP3 activation correlating positively with disease severity (Yi, 2020)

Chiovato L, Marcocci C, Mariotti S, Mori A, Pinchera A

Keep your semaglutide pens in the refrigerator until youre ready to use them

Experiencing low blood pressure and a high heart rate can be concerning, but not every case requires an urgent care visit or emergency room trip