For tirzepatide (Zepbound) Jastreboff and colleagues reported in the New England Journal of Medicine in 2022 that at maximal doses, the percent of individuals reporting side effects were as follows: Nausea 31.0% Diarrhea 23.0% Vomiting 12.2% Constipation 11.7% Bettge and colleagues conducted a study published in Diabetes, Obesity, and Metabolism in 2017 that showed that individuals who were taking metformin while taking a GLP-1 were more likely to have side effects, especially nausea and vomiting
While both forms of GLP-1 weight loss medication target the same biological pathways to increase fullness and slow digestion, the route of delivery changes how the body processes the active molecules
Ongoing research suggests that GLP-1s may expand into treatments for neurodegenerative conditions, gastrointestinal diseases, liver problems, kidney disease, and more
Constipation Due to a lack of essential nutrients caused by restricted food intake, weight-loss drugs can lead to constipation, as the body doesnt receive the necessary nutrients to maintain proper digestive function
It may also be used as a maintenance dose after significant weight loss has already been achieved, she added