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Study conceptualization, design, data collection, analysis, decision to publish, or preparation of the manuscript was done under the supervision and according to the regulations of the Vice Chancellor for Research at Ahvaz Jundishapur University of Medical Sciences

In vitro knock-in of scExe4 Hepa1-6 cells were transfected with scExe4 donor plasmid alone (Donor) or scExe4 donor plasmid with Cas9 plasmid (Donor+Cas9), each 1 g in 12-well plates using Lipofectamine 3000

Studies indicate that people 65 and older survive an average of four to eight years after a diagnosis of Alzheimer's dementia, yet some live as long as 20 years

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