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GLP-1 receptor agonists, such as semaglutide and liraglutide, are widely prescribed in the UK for type 2 diabetes and weight management

In vitro incubation studies have shown that fructose undergoes degradation to form a range of reactive carbonyl compounds, including formaldehyde, with total degradation product yields being 4.6- 271.6-fold higher than those from glucose, potentially contributing to its stronger metabolic reactivity and association with insulin resistance [2]

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In addition the market for weight loss drugs was considered too small to be commercially viable (Gilbert, Rosenthal, Jan 2024

Ileus and Intestinal Obstruction/ Bowel blockage: Lawsuits claim the drug can cause life-threatening partial or complete blockages of the intestines