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In order to choose the most suitable development direction for small and medium-sized towns, it is necessary to consider besides regional development plans, the possibilities and potentials of the space at the local level taking into account the long-term needs of the inhabitants

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PARP enzymes, especially PARP1, play a pivotal role in DNA repair by detecting and signaling DNA damage

However, considering the role of oxidative stress in DPN pathology, as well as identified mechanisms by which ALA may alleviate DPN symptoms, it would seem reasonable to assume that regular intake of ALA (e.g., 300 600 mg/d) may offer some protection against developing DPN symptoms, even when used as a monotherapy

Mechanisms of sterile inflammation after intravitreal injection of antiangiogenic drugs: a narrative review