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What Plaintiffs Allege Failure to warn of side effects

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Metformin is the first line of treatment in newly discovered T2D patients and was first demonstrated to influence gut microbiota composition in diet induced obese mouse models, where it resulted in enrichment of Akkermansia muciniphila (39, 40), a gut commensal showing beneficial effects on metabolism (41)

Its mechanism involves enhancing insulin secretion, suppressing glucagon, and slowing gastric emptying, all contributing to a prolonged feeling of fullness

SSRI use during pregnancy could result in lifelong consequences on the brain in offspring (134), but the underlying mechanism is complex, including fetal exposure to SSRIs and alterations of 5-HT supply from the placenta