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The GHRP component appeared to sensitize somatotrophs to GHRH by mobilizing intracellular calcium stores through the Gq pathway, while GHRH simultaneously elevated cAMP via Gs

Day 8 was selected to assess the CLs blood flow, biometry, and secretary potency because it was considered the critical period for CL functionality (from Day 5 to Day 10) and development [44]

Importantly, they can also convert indigestible carbohydrates into short-chain fatty acids (SCFA), which in turn activate specific G protein-coupled fatty acid (FFA) receptors, thereby promoting the secretion of peptide hormones from the enteroendocrine cells [106, 107]