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Seek urgent medical attention if you experience: Severe, persistent abdominal pain (especially if radiating to the back) with or without vomiting, which could indicate pancreatitis Right upper quadrant pain, fever, or yellowing of the skin/eyes, which might suggest gallbladder disease Severe chest pain, difficulty breathing, facial swelling, or signs of an allergic reaction For urgent advice, call NHS 111
9 Challenges and limitations to compliance with GLP-1 RA therapy While GLP-1 RA therapies are highly effective for glycemic control and weight loss, real-world data indicate that many patients either discontinue or struggle to adhere to these treatments
At high doses, topiramate may also decrease the effectiveness of oral combined hormonal contraceptives and therefore, alternative or additional contraceptive methods should be offered
From a safety perspective, the available semaglutide data indicate that adverse events are predominantly gastrointestinal, most commonly nausea, diarrhea, vomiting and constipation, without a clear thyroid-specific carcinogenic signal (193)
