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In February 2021, the researchers published findings from the STEP 1 trial in The New England Journal of Medicine showing that patients who injected semaglutide lost close to 15% of their body weight, on average, compared with 2.4% among patients receiving the placebo

In late-stage trials, the once-daily oral treatment helped overweight adults without diabetes lose 12.4% of their body weight over 72 weeks at the highest dose

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