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If you've had a BAD experience with B12 shots, it's most likely that you do not tolerate or convert cyanocobalamin well (see if you can verify what form of B12 was in the shot that made you react poorly, and then stay away from that specific form if you can)

However, environmental factors and handling protocols can affect a peptides structure and increase the rate of degradation (Walker & Fleming, 1993)

Some practitioners extend treatment to 6 months, though this remains controversial

If taking overthecounter supplements, ask whether the dose should be adjusted

Instead of puncturing the same stopper 30 or 40 times over a month, you puncture each smaller vial only a few times