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2022;28:e324

Abbreviations A : Amyloid beta ALS: Amyotrophic lateral sclerosis BH3: Bcl-2 homology domain-3 BSA: Bovine serum albumin BSO: Buthionine sulfoximine CGN: Cerebellar granule neuron DAPI: 4,6-Diamidino-2-phenylindole -GCL: -Glutamyl-cysteine ligase GSH: Glutathione GSH-MEE: Glutathione monoethylester GSS: Glutathione synthase HA14-1: 2-Amino-6-bromo- -cyano-3-(ethoxycarbonyl)-4H-1-benzopyran-4-acetic acid ethyl ester ICAL: Immunocal NAC: N-Acetyl cysteine NMDA: N-Methyl-D-aspartate Nrf2: Nuclear factor erythroid 2-related factor-2 ROS: Reactive oxygen species RNS: Reactive nitrogen species SOD1: Copper-zinc superoxide dismutase SNP: Sodium nitroprusside Sx c : System x c TDP-43: TAR DNA binding protein-43

It has demonstrated the ability to reduce body weight by more than 20% in individuals with obesity (118), and to improve glycemic control to a degree that 87-91% of enrolled individuals with type 2 diabetes reach HbA1c levels below the type 2 diabetes diagnostic threshold after 40 weeks of treatment (120)