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Chapman LE, Darling AL, Brown JE (2015) The association between the biguanide drug metformin and vitamin B 12 deficiency in diabetic patients: a systematic review

Many patients report a noticeable boost in energy and mental clarity within days of their first injection

Such effects could be related to pain-modulating properties observed with GH in other studies

Defy's version, for example, uses thiamine (B1) where Empower uses carnitine as the headline addition