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Semaglutide and tirzepatide are dosed weekly because their half-lives are built around a weekly schedule to maintain steadier blood levels

Many patients report significant changes in hunger levels, fullness cues, and even food preferences

Chronic unpredictable stress, considered a model of depression, results in a reduction in dendritic lengths and branching of apical dendrites, the loss of functional synaptic spines, and the reduction of dendritic complexity in PFC neurons and in the hippocampal CA3 pyramidal neuronal cell layer (McEwen et al., 2012

Sip water consistently throughout the day

They also affect signals in the brain linked to feelings of fullness and satisfaction, tamping down appetite, food-related thoughts and cravings