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Cummings JL, Atri A, Feldman HH, Hansson O, Sano M, Knop FK, Johannsen P, Len T, Scheltens P

In addition, metformin-induced AMPK activation promotes activation of the SIRT1/PGC-1 pathway suggesting interplay between AMPK and SIRT1/PGC-1 in the neuroprotective effect of metformin

Aberrant activation of specific transcriptional programs has the capacity to greatly alter cellular state, driving oncogenesis and supporting cancer cell proliferation

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