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Currently available pharmacotherapeutics options in HF mostly remain focused on HFrEF, where treatments strategies aim at relief of symptoms, improving quality of life, and prolonging the life of the affected individual (McDonagh et al., 2021

Patients with these conditions should consult their doctor or visit urgent care or an emergency room for proper medical attention

That predictable frustration is real and points to the next question that matters most

For instance, certain NOX members, such as NOX4, are overexpressed in various types of cancer (e.g., hepatocellular carcinoma and renal cell carcinoma) [19, 20]

Although power was maintained, approximately 23% of participants across both groups withdrew before trial completion