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Prostaglandin D 2 and E 2 are unstable and will easily be converted to prostaglandin J 2 and A 2 , respectively and their derivatives inhibit NFB, [66] a family of transcription factors that regulate the transcription of genes important for inflammatory processes

While this side effect is rare, semaglutide may cause dry mouth for a number of reasons , including its tendency to cause dehydration, which affects saliva production