Why Are GLP-1 and Peptide Therapies Becoming Popular
Additional dual agents that target GLP-1 and GIP include Tirzepatide, which has shown to provide greater glycemic control compared to available single agonist agents
Unlike single- or dual-pathway compounds, it is a GIP, GLP-1, and glucagon triple receptor agonist , meaning it simultaneously activates the receptors for glucose-dependent insulinotropic polypeptide (GIP), glucagon-like peptide-1 (GLP-1), and glucagon
Called Byetta (exenatide) and originally developed by Amylin Pharmaceuticals, the drug was later marketed by AstraZeneca
5 Similarly, Vilsbll found in a post hoc mediation analysis of SUSTAIN 6 that the large and rapid reduction of HbA 1c percentage in patients on semaglutide seemed to drive the DR complications observed in that group