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While patients should generally not discontinue tirzepatide without medical guidance due to potential glycemic deterioration, they should immediately stop the medication and seek urgent medical care if they develop symptoms of pancreatitis (severe, persistent abdominal pain, sometimes radiating to the back) or serious allergic reactions

For most GLP-1 users in a moderate fat loss phase, 120 to 140 grams per day is a solid working target at this goal weight

Moreover, GLP-1 and GLP-1 receptor agonists increase satiety, leading to a reduction in weight (95)

2009;6 Moher D, Liberati A, Tetzlaff J, et al

The mechanism is well-defined