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8.6 Renal Impairment Compared to healthy volunteers with normal renal function, patients with moderate and severe renal impairment as estimated by the Cockcroft-Gault equation had higher exposures to phentermine and topiramate

As underling mechanism of the interaction between afferent and efferent renal nerves our previous report [24] has shown that activation of afferent renal nerves leads to activation of efferent renal sympathetic nerves response to GLP-1, possibly via central neural reflex in normal rats

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Their findings revealed a 30% reduction in MACE compared to monotherapy

It works by blocking the NNMT enzyme in fat cells and other tissues, which prevents the conversion of nicotinamide to 1-methylnicotinamide